“Mineralys Therapeutics is a clinical-stage biopharmaceutical company focused on developing medicines to target hypertension and related comorbidities such as chronic kidney disease (CKD), obstructive sleep apnea (OSA) and other diseases driven by dysregulated aldosterone. Its initial product candidate, lorundrostat, is a proprietary, orally administered, highly selective aldosterone synthase inhibitor. Mineralys is headquartered in Radnor, Pennsylvania. For more information, please visit https://mineralystx.com. Follow Mineralys on LinkedIn, Twitter and Bluesky”

Mineralys is a fully remote company.

The Director of Accounting is a key leadership role within the growing Finance organization, responsible for overseeing the general ledger. This role will lead the build‑out and ongoing optimization of our accounting infrastructure to support commercial product launch, revenue recognition under ASC 606, inventory and cost of goods sold (COGS) accounting, and gross‑to‑net (GTN) processes. The ideal candidate brings deep public company and commercial‑stage experience in life sciences, strong technical accounting expertise, and a proven track record of leading high‑performing teams in a SOX‑compliant environment. This position is remote based with regular in person meetings with the Finance team in the Boulder, CO region.

Principal Responsibilities

Lead the overall accounting function, including general ledger, accounts payable, payroll accounting, revenue, inventory/COGS, fixed assets, and equity compensation.
Own the monthly, quarterly, and annual close processes, ensuring accurate and timely preparation of financial statements in accordance with U.S. GAAP and company policies.
Establish and oversee commercial accounting processes for product revenue, including contract review, revenue recognition under ASC 606, and accounting for variable consideration and gross‑to‑net deductions (e.g., chargebacks, rebates, copay assistance, returns).
Design and implement inventory and COGS accounting processes to support commercial manufacturing, distribution, and supply chain activities in partnership with Technical Operations and Supply Chain teams.
Lead the development, documentation, and maintenance of robust accounting policies, procedures, and internal controls, ensuring SOX compliance and scalability as the company grows.
Support external financial reporting processes in partnership with SEC reporting resources, including support for 10‑Q/10‑K filings, earnings materials, and other regulatory or lender reporting, as applicable.
Serve as primary point of contact for external auditors on all accounting and internal control matters, managing audit requests and driving issue resolution.
Evaluate complex and non‑routine transactions (e.g., collaborations, licensing, debt, equity, business combinations, stock‑based compensation) and prepare or review technical accounting analyses and memos.
Drive continuous improvement and automation across accounting operations, including optimal use of ERP and related systems (e.g., NetSuite, FloQast, Tipalti, payroll platforms) to improve efficiency, accuracy, and visibility.
Build, lead, and develop a high‑performing accounting team, providing coaching, clear objectives, and career development opportunities.

Skills And Attributes

Deep technical knowledge of U.S. GAAP, including ASC 606 (Revenue from Contracts with Customers), ASC 842 (Leases), and accounting for inventory, equity compensation, and complex arrangements.
Significant experience in a commercial‑stage biopharmaceutical, biotech, or life sciences company with responsibility for product revenue and gross‑to‑net accounting.
Proven track record building and leading high‑performing accounting teams in a fast‑paced, high‑growth, public company environment.
Strong understanding of SOX requirements and experience designing, implementing, and maintaining internal controls over financial reporting.
Hands‑on, detail‑oriented, and process‑minded with a continuous improvement mindset.
Excellent analytical, problem‑solving, and decision‑making skills, with the ability to navigate complex and ambiguous issues.
Effective communicator with the ability to convey complex accounting matters to non‑finance stakeholders.
High degree of integrity, sound judgment, and commitment to ethical business practices and compliance.
Proficiency with ERP and financial systems (ideally NetSuite) and close‑management or automation tools such as FloQast, as well as AP and procurement solutions such as Tipalti.

Supervisory Responsibility

This role has direct supervisory responsibility for accounting staff and managers, including general ledger, accounting operations, and other functional leads as the team scales.

Travel

This position requires up to 10 % travel. Frequently travel is outside the local area and overnight.

Education And Experience

Bachelor’s degree in Accounting or Finance is required; CPA strongly preferred. Advanced degree is a plus.
12+ years of progressive accounting experience, including significant leadership responsibility at the Senior Manager or Director level in a public company environment.
Prior experience in the biopharmaceutical, biotech, or broader life sciences industry is strongly preferred.
Demonstrated experience supporting or leading accounting for commercial product launches, including revenue recognition and gross‑to‑net accounting.
Strong background in managing audits and working with external auditors, including Big 4 or large regional firms.
Experience implementing or optimizing ERP and related finance systems (e.g., NetSuite, FloQast, Tipalti, payroll platforms).
Proven success in building and scaling accounting processes and teams in a high‑growth, SOX‑compliant environment.

This position is eligible for standard Company benefits including medical, dental, vision, time off and 401K, as well as participating in Mineralys incentive plans are contingent on achievement of personal and company performance. Actual compensation may vary from posted hiring range based on geographic location, work experience, education, and/or skill level.

US Salary Range: $175,000 - $195,000

Mineralys Therapeutics, Inc.

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